Publications

Conference Abstracts      Google Scholar       PubMed       ORCID      

Wheeler Lab Member     *Masters Student     #Undergraduate

2021

#*Mulford AJ, Wing C, Dolan ME, Wheeler HE. (2021) Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations. Hum Mol Genet, Online ahead of print. DOI

*Okoro PC, *Schubert R, Guo X, Johnson WC, Rotter JI, Hoeschele I, Liu Y, Im HK, Luke A, Dugas LR, Wheeler HE. (2021) Transcriptome prediction performance across machine learning models and diverse ancestries. HGG Advances, Online ahead of print. DOI

2020

#*Geoffroy E, #Gregga I, Wheeler HE. (2020) Population-matched transcriptome prediction increases TWAS discovery and replication rate. iScience 23(12):101850. PMC7721644 DOI

*Schubert R, #*Andaleon A, Wheeler HE. (2020) Comparing local ancestry inference models in populations of two- and three-way admixture. PeerJ 8:e10090. PMC7537619 DOI

Trendowski MR, Wheeler HE, El Charif O, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Einhorn LH, Travis LB, Dolan ME. (2020) Clinical and genome-wide analysis of multiple severe cisplatin-induced neurotoxicities in adult-onset cancer survivors. Clinical Cancer Research 26(24):6550-6558. PMC7744329 DOI

#Fiorica PN, *Schubert R, #Morris JD, #Abdul Sami M, Wheeler HE. (2020) Multi-ethnic transcriptome-wide association study of prostate cancer. PLOS ONE 15(9):e0236209. PMC7521738 DOI

Barbeira AN, Liang Y, Bonazzola R, Wang G, Wheeler HE, Melia OJ, Aguet F, GTEx Consoritum, Ardlie KG, Wen X, Im HK. (2020) Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification. Genetic Epidemiology 44(8):854-867. PMC7693040 DOI

2019

Mohammadi P, Castel SE, Cummings BB, Einson J, Sousa C, Hoffman P, Donkervoort S, Jiang Z, Mohassel P, Foley R, Wheeler HE, Im HK, Bonnemann CG, MacArthur DG, Lappalainen T. (2019) Genetic regulatory variation in populations informs transcriptome analysis in rare disease. Science 366(6463):351-356. PMC6814274 DOI

#Fiorica PN and Wheeler HE. (2019) Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophrenia. PeerJ 7:e7778. PMID31579629 DOI

Trendowski MR, El Charif O, Ratain M, Monahan P, Mu Zepeng, Wheeler HE, Dinh PC, Feldman DR, Ardeshir-Rouhani-Fard S, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Hannigan R, Strathmann F, Einhorn LH, Fossa SD, Travis LB, Dolan ME. (2019) Clinical and genome-wide analysis of serum platinum levels after cisplatin-based chemotherapy. Clinical Cancer Research 25(19):5913-5924. PMID31296530 DOI

Wheeler HE, #Ploch S, Barbeira AN, Bonazzola R, #*Andaleon A, Fotuhi Sishpirani A, Saha A, Battle A, Roy S, Im HK. Imputed gene associations identify replicable trans-acting genes enriched in transcription pathways and complex traits. Genetic Epidemiology (2019) 43(6):596-608. PMID30950127 DOI

#*Andaleon A, Mogil LS, Wheeler HE. Genetically regulated gene expression underlies lipid traits in Hispanic cohorts. (2019) PLOS ONE 14(8):e0220827. PMID31393916 DOI

El Charif O, Mapes B, Trendowski MR, Wheeler HE, Wing C, Dinh PC, Frisina RD, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Gamazon ER, Cox N, Huddart R, Ardeshir-Rouhani-Fard S, Monahan P, Fossa SD, Einhorn LH, Travis LB, Dolan ME. (2019) Clinical and genome-wide analysis of cisplatin-induced tinnitus implicates novel ototoxic mechanisms. Clinical Cancer Research 25(13):4104-4116. PMID30952644 DOI

Barbeira AN, Pividori MD, Zheng J, Wheeler HE, Nicolae DL, Im HK. (2019) Integrating predicted transcriptome from multiple tissues improves association detection. PLOS Genetics 15(1):e1007889. PMID30668570 DOI

Boomgarden AC, Sagewalker GD, Shah AC, Haider SD, Patel P, Wheeler HE, Dubowy CM, Cavanaugh DJ. (2019) Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila. BMC Genomics 20(1):14. PMID30616504 DOI

2018

Mogil LS, #*Andaleon A, #Badalamenti A, Dickinson SP, Guo X, Rotter JI, Johnson WC, Im HK, Liu Y, Wheeler HE. (2018) Genetic architecture of gene expression traits across diverse populations. PLOS Genetics 14(8):e1007586. PMID30096133 DOI

Wyss AB, Sofer T, Lee MK, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AV, Bartz TM, Feitosa MF, Gao W, Ahluwalia TS, Tang W, Oldmeadow C, Duan Q, de Jong K, Wojczynski MK, Wang XQ, Noordam R, Hartwig FP, Jackson VE, Wang T, Obeidat M, Hobbs BD, Huan T, Gui H, Parker MM, Hu D, Mogil LS, Kichaev G, Jin J, Graff M, Harris TB, Kalhan R, Heckbert SR, Paternoster L, Burkart KM, Liu Y, Holliday EG, Wilson JG, Vonk JM, Sanders JL, Barr RG, de Mutsert R, Menezes AMB, Adams HHH, van den Berge M, Joehanes R, Levin AM, Liberto J, Launer LJ, Morrison AC, Sitlani CM, Celedón JC, Kritchevsky SB, Scott RJ, Christensen K, Rotter JI, Bonten TN, Wehrmeister FC, Bossé Y, Xiao S, Oh S, Franceschini N, Brody JA, Kaplan RC, Lohman K, McEvoy M, Province MA, Rosendaal FR, Taylor KD, Nickle DC, Williams LK, Burchard EG, Wheeler HE, Sin DD, Gudnason V, North KE, Fornage M, Psaty BM, Myers RH, O’Connor G, Hansen T, Laurie CC, Cassano PA, Sung J, Kim WJ, Attia JR, Lange L, Boezen HM, Thyagarajan B, Rich SS, Mook-Kanamori DO, Horta BL, Uitterlinden AG, Im HK, Cho MH, Brusselle GG, Gharib SA, Dupuis J, Manichaikul A, London SJ. (2018) Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nature Communications 9(1):2976. PMID30061609 DOI

Li R, Kim D, Wheeler HE, Dudek SM, Dolan ME, Ritchie MD. (2018) Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity. The Pharmacogenomics Journal Epub 2018 May 25. PMID29795408 DOI

Barbeira AN, Dickinson SP, Bonazzola R, Zheng J, Wheeler HE, Torres JM, Torstenson ES, Shah KP, Garcia T, Edwards TL, Stahl EA, Huckins LM, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. (2018) Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nature Communications 9(1):1825. PMID29739930 DOI

#*Andaleon A, Mogil LS, Wheeler HE. (2018) Gene-based association study for lipid traits in diverse cohorts implicates BACE1 and SIDT2 regulation in triglyceride levels. PeerJ 6:e4314. PMID29404214 DOI

2017

Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton R, Vaughn DJ, Beard C, Fung C, Fossa SD, Hertz DL, Mushiroda T, Kubo M, Einhorn LH, Cox N, Travis L. (2017) Clinical and genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer. Clinical Cancer Research 23(19):5757-5768. PMID28611204

Wheeler HE, Gamazon ER, Frisina R, #Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman D, Hamilton R, Vaughn DJ, Beard C, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox N, Dolan ME, Travis L. (2017) Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Clinical Cancer Research 23(13):3325-33. PMID28039263Highlights Feature

Wing C, Komatsu M, Delaney SM, Krause M, Wheeler HE, Dolan ME. (2017) Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy. Stem Cell Research 22:79-88. PMID28645005

Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME. (2017) Genetic variants contributing to colistin cytotoxicity: identification of TGIF1 and HOXD10 using a population genomics approach. International Journal Molecular Sciences 18(3). PMC5372673

2016

Wheeler HE, Shah KP, *Brenner J, Garcia T, Aquino-Michaels K, GTEx Consortium, Cox NJ, Nicolae DL, Im HK. (2016) Survey of the heritability and sparsity of gene expression traits across human tissues. PLOS Genetics 12(11):e1006423. PMC5106030

Frisina RD, Wheeler HE, Fossa SD, Kerns SL, Fung C, Sesso HD, Monahan PO, Feldman DR, Hamilton R, Vaughn DJ, Beard CJ, Budnick A, Johnson EM, Ardeshir-Rouhani-Fard S, Einhorn LH, Lipshultz SE, Dolan ME, Travis LB. (2016) Comprehensive audiometric analysis of hearing impairment and tinnitus after cisplatin-based chemotherapy in survivors of adult-onset cancer. Journal of Clinical Oncology 34(23):2712-20. PMC5019759 Contributed equally.

Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel JN, Halabi S, Furukawa Y, Wheeler HE, Sibley A, Lassiter C, Weisman LS, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz D, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL. (2016) Pharmacogenetic discovery in CALGB (Alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy. Clinical Cancer Research 22(19):4890-4900. PMC5050068

2015

Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. (2015) A gene-based association method for mapping traits using reference transcriptome data. Nature Genetics 47(9):1091-8. PMC4552594 Contributed equally.

Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, Gorsic LK, Takahashi A, Kubo M, Kroetz D, Zhang W, Nakamura Y, Dolan ME. (2015) Pharmacoethnicity in paclitaxel-induced sensory peripheral neuropathy. Clinical Cancer Research 21(19):4337-46. PMC4592389

Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng JJ, Yang W, Fan Y, Wheeler HE, Wing C, Delaney SM, Komatsu M, Paugh SW, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui CH, Dolan ME, Relling MV, Evans WE. (2015) Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. JAMA 313(8):815-823. PMC4377066

Wheeler HE, Wing C, Delaney SM, Komatsu M, Dolan ME. (2015) Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells. PLOS One 10(2):e0118020. PMC4331516

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