2014
Thompson P, Wheeler HE, Delaney SM, Lorier R, Broeckel U, Devidas M, Reaman GH, Scorsone K, Sung L, Dolan ME, Berg SL. (2014) Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children’s Oncology Group. Cancer Chemotherapy and Pharmacology, 74(4):831-8. PMC4282931
Wheeler HE, Aquino-Michaels K, Gamazon ER, Trubetskoy VV, Dolan ME, Huang RS, Cox NJ, Im HK (2014) Poly-omic prediction of complex traits: OmicKriging. Genetic Epidemiology, 38(5):402-15. PMC4072756 International Genetic Epidemiology Society Robert C. Elston Best Paper Award 2014
Wheeler HE, González-Neira A, Pita G, de la Torre-Montero JC, Alonso R, Lopez-Fernandez LA, Alba E, Martín M, Dolan ME (2014) Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell line genomic analyses. Pharmacogenetics and Genomics 24(5):231-7. PMC4076106
2013
Gorsic LK, Stark AL, Wheeler HE, Wong SS, Im HK, Dolan ME (2013) EPS8 inhibition increases cisplatin sensitivity in lung cancer cells. PLOS One 8(12):e82220. PMC3868552
Parsa A, Fuchsberger C…Wheeler HE…Böger CA (>100 authors) (2013) Common variants in Mendelian kidney disease genes and their association with renal function. Journal of the American Society of Nephrology 24(12):2105-17. PMC3839542
Eadon MT, Wheeler HE, Stark AL, Zhang X, Moen EL, Delaney SM, Im HK, Cunningham PN, Zhang W, Dolan ME (2013) Genetic and epigenetic variants contributing to clofarabine cytotoxicity. Human Molecular Genetics 22(19):4007-20. PMC3766179
Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME (2013) Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients. Blood 121(21):4366-76. PMC3663430
Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer E, Hudis C, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cox NJ, Dolan ME (2013) Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy. Clinical Cancer Research 19(2):491-9. PMC3549006
Wheeler HE, Maitland ML, Dolan ME, Cox NJ, Ratain MJ (2013) Cancer pharmacogenomics: strategies and challenges. Nature Reviews Genetics 14(1):23-34. PMC3668552
Wheeler HE, Gamazon ER, Stark AL, O’Donnell PH, Gorsic LK, Huang RS, Cox NJ, Dolan ME (2013) Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. The Pharmacogenomics Journal 13(1):35-43. PMC3370147
2012
Chasman DI, Fuchsberger C…Wheeler HE…Kao WH, Fox CS, Kottgen A (>100 authors) (2012) Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Human Molecular Genetics 21(24):5329-43. PMC3607468
Cox NJ, Gamazon ER, Wheeler HE, Dolan ME (2012) Clinical translation of cell-based pharmacogenomic discovery. Clinical Pharmacology & Therapeutics 92(4):425-7. PMC3664667
Madian AG, Wheeler HE, Jones RB, Dolan ME (2012) Relating human genetic variation to variation in drug responses. Trends in Genetics 28(10):487-95. PMC3448823
Stark AL, Delaney SM, Wheeler HE, Im HK, Dolan ME (2012) Functional consequences of PRPF39 on distant genes and cisplatin sensitivity. Human Molecular Genetics 21(19):4348-55. PMC3441128
Leandro-Garcia LJ, Lekela S, Jara Sanchez C, Green H, Avall Lundqvist E, Wheeler HE, Dolan ME, Inglada-Perez L, Maliszewska A, de Cubas AA, Comino-Mendez I, Mancikova V, Cascon A, Robledo M, Rodriguez-Antona C (2012) Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy. Clinical Cancer Research 18(16):4441-8. PMC3664665
O’Donnell PH, Stark AL, Gamazon ER, Wheeler HE, McIlwee BE, Gorsic LK, Im HK, Huang RS, Cox NJ, Dolan ME (2012) Identification of novel germline polymorphisms governing capecitabine sensitivity. Cancer 118(16):4063-73. PMC3413892
Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA…Wheeler HE…Kao WH, Fox CS (>100 authors) (2012) Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584. PMC3315455
Njiaju UO, Gamazon ER, Gorsic LK, Delaney SM, Wheeler HE, Im HK, Dolan ME (2012) Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel. Pharmacogenetics and Genomics 22(7): 498-507. PMC3376193
Wheeler HE and Dolan ME. (2012) Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. Pharmacogenomics 13(1):55-70. PMC3292907
2011
Wheeler HE, Gorsic LK, Welsh M, Stark AL, Gamazon ER, Cox NJ, Dolan ME. (2011) Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One 6(7): e21920. PMC3130766
Wen Y, Gorsic LK, Wheeler HE, Ziliak DM, Huang RS, Dolan ME. (2011) Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies. Pharmacogenetics and Genomics 21(8): 476-88. PMC3134538
Wheeler HE and Kim SK (2011) Genetics and genomics of human ageing. Philosophical Transactions of the Royal Society B 366(1561): 43-50. PMC3001305
2009
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. (2009) Sequential use of transcriptional profiling, expression quantitative trait mapping and gene association implicates MMP20 in human kidney aging. PLoS Genetics 5(10): e1000685. PMC2752811