Conference Abstracts Google Scholar PubMed ORCID
Wheeler Lab Member *Masters Student #Undergraduate
2024
#*Wittich H, Ardlie K, Taylor KD, Durda P, Liu Y, Mikhaylova A, Gignoux CR, Cho MH, Rich SS, Rotter JI; NHLBI TOPMed Consortium; Manichaikul A, Im HK, Wheeler HE. (2024) Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits. American Journal of Human Genetics 111(3):445-455. PMID DOI
2023
#Gregga I, Pharoah PD, Gayther SA, Manichaikul A, Im HK, Kar SP, Schlidkraut JM, Wheeler HE. (2023) Predicted proteome association studies of breast, prostate, ovarian, and endometrial cancers implicate plasma protein regulation in cancer susceptibility. Cancer Epidemiol Biomarkers Prev 32(9):1198-1207. PMC10528410 DOI
*Araújo DS, #Nguyen C, Hu X, Mikhaylova AV, Gignoux C, Ardlie K, Taylor KD, Durda P, Liu Y, Papanicolaou G, Cho MH, Rich SS, Rotter JI; NHLBI TOPMed Consortium; Im HK, Manichaikul A, Wheeler HE. (2023) Multivariate adaptive shrinkage improves cross-population transcriptome prediction for transcriptome-wide association studies in underrepresented populations. HGG Advances 4(4):100216. PMC10589725 DOI
Hou K, Ding Y, Xu Z, Wu Y, Bhattacharya A, Mester R, Belbin GM, Buyske S, Conti DV, Darst BF, Fornage M, Gignoux C, Guo X, Haiman C, Kenny EE, Kim M, Kooperberg C, Lange L, Manichaikul A, North KE, Peters U, Rasmussen-Torvik LJ, Rich SS, Rotter JI, Wheeler HE, Wojcik GL, Zhou Y, Sankararaman S, Pasaniuc B. (2023) Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Nature Genetics 55(4):549-558. DOI
2022
*Araújo DS and Wheeler HE. (2022) Genetic and environmental variation impact transferability of polygenic risk scores. Cell Reports Medicine 3(7):100687. PMC9381406 DOI
Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, Bartz TM, Kumar R, Li X, Yu B, Cade BE, Laurie CA, Sofer T, Ruczinski I, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Gabriel S, Gupta N, Dugan-Perez S, Cupples LA, Loehr LR, Jain D, Rotter JI, Wilson JG, Psaty BM, Fornage M, Morrison AC, Vasan RS, Washko G, Rich SS, O’Connor GT, Bleecker E, Kaplan RC, Kalhan R, Redline S, Gharib SA, Meyers D, Ortega V, Dupuis J, London SJ, Lappalainen T, Oelsner EC, Silverman EK, Barr RG, Thornton TA, Wheeler HE; TOPMed Lung Working Group, Cho MH, Im HK, Manichaikul A. (2022) Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. American Journal of Human Genetics 109(5):857-870. PMC9118106 DOI
*Schubert R, #*Geoffroy E, #Gregga I, #*Mulford AJ, Aguet F, Ardlie K, Gerszten R, Clish C, Van Den Berg D, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy R, Conomos M, Blackwell T, Papanicolaou G, Lappalainen T, Mikhaylova AV, Thornton TA, Cho MH, Gignoux CR, Lange L, Lange E, Rich SS, Rotter JI; NHLBI TOPMed Consortium, Manichaikul A, Im HK, Wheeler HE. (2022) Protein prediction for trait mapping in diverse populations. PLOS ONE 17(2):e0264341. PMC8870552 DOI
Liang Y, Pividori M, Manichaikul A, Palmer AA, Cox NJ, Wheeler HE, Im HK. (2022) Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries. Genome Biology 23(1):23. PMC8759285 DOI
2021
Trendowski MR, Baedke JL, Sapkota Y, Travis LB, Zhang X, El Charif O, Wheeler HE, Leisenring WM, Robison LL, Hudson MM, Morton LM, Oeffinger KC, Howell RM, Armstrong GT, Bhatia S, Dolan ME. (2021) Clinical and genetic risk factors for radiation-associated ototoxicity: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort. Cancer 127(21):4091-4102. PMC8516694 DOI
#*Mulford AJ, Wing C, Dolan ME, Wheeler HE. (2021) Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations. Human Molecular Genetics 30(3-4):305-317. PMC8248963 DOI
*Okoro PC, *Schubert R, Guo X, Johnson WC, Rotter JI, Hoeschele I, Liu Y, Im HK, Luke A, Dugas LR, Wheeler HE. (2021) Transcriptome prediction performance across machine learning models and diverse ancestries. HGG Advances 2(2):100019. PMC8087249 DOI
2020
#*Geoffroy E, #Gregga I, Wheeler HE. (2020) Population-matched transcriptome prediction increases TWAS discovery and replication rate. iScience 23(12):101850. PMC7721644 DOI
*Schubert R, #*Andaleon A, Wheeler HE. (2020) Comparing local ancestry inference models in populations of two- and three-way admixture. PeerJ 8:e10090. PMC7537619 DOI
Trendowski MR, Wheeler HE, El Charif O, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Einhorn LH, Travis LB, Dolan ME. (2020) Clinical and genome-wide analysis of multiple severe cisplatin-induced neurotoxicities in adult-onset cancer survivors. Clinical Cancer Research 26(24):6550-6558. PMC7744329 DOI
#Fiorica PN, *Schubert R, #Morris JD, #Abdul Sami M, Wheeler HE. (2020) Multi-ethnic transcriptome-wide association study of prostate cancer. PLOS ONE 15(9):e0236209. PMC7521738 DOI
Barbeira AN, Liang Y, Bonazzola R, Wang G, Wheeler HE, Melia OJ, Aguet F, GTEx Consoritum, Ardlie KG, Wen X, Im HK. (2020) Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification. Genetic Epidemiology 44(8):854-867. PMC7693040 DOI
2019
Mohammadi P, Castel SE, Cummings BB, Einson J, Sousa C, Hoffman P, Donkervoort S, Jiang Z, Mohassel P, Foley R, Wheeler HE, Im HK, Bonnemann CG, MacArthur DG, Lappalainen T. (2019) Genetic regulatory variation in populations informs transcriptome analysis in rare disease. Science 366(6463):351-356. PMC6814274 DOI
#Fiorica PN and Wheeler HE. (2019) Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophrenia. PeerJ 7:e7778. PMID31579629 DOI
Trendowski MR, El Charif O, Ratain M, Monahan P, Mu Zepeng, Wheeler HE, Dinh PC, Feldman DR, Ardeshir-Rouhani-Fard S, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Hannigan R, Strathmann F, Einhorn LH, Fossa SD, Travis LB, Dolan ME. (2019) Clinical and genome-wide analysis of serum platinum levels after cisplatin-based chemotherapy. Clinical Cancer Research 25(19):5913-5924. PMID31296530 DOI
Wheeler HE, #Ploch S, Barbeira AN, Bonazzola R, #*Andaleon A, Fotuhi Sishpirani A, Saha A, Battle A, Roy S, Im HK. Imputed gene associations identify replicable trans-acting genes enriched in transcription pathways and complex traits. Genetic Epidemiology (2019) 43(6):596-608. PMID30950127 DOI
#*Andaleon A, Mogil LS, Wheeler HE. Genetically regulated gene expression underlies lipid traits in Hispanic cohorts. (2019) PLOS ONE 14(8):e0220827. PMID31393916 DOI
El Charif O, Mapes B, Trendowski MR, Wheeler HE, Wing C, Dinh PC, Frisina RD, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Gamazon ER, Cox N, Huddart R, Ardeshir-Rouhani-Fard S, Monahan P, Fossa SD, Einhorn LH, Travis LB, Dolan ME. (2019) Clinical and genome-wide analysis of cisplatin-induced tinnitus implicates novel ototoxic mechanisms. Clinical Cancer Research 25(13):4104-4116. PMID30952644 DOI
Barbeira AN, Pividori MD, Zheng J, Wheeler HE, Nicolae DL, Im HK. (2019) Integrating predicted transcriptome from multiple tissues improves association detection. PLOS Genetics 15(1):e1007889. PMID30668570 DOI
Boomgarden AC, Sagewalker GD, Shah AC, Haider SD, Patel P, Wheeler HE, Dubowy CM, Cavanaugh DJ. (2019) Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila. BMC Genomics 20(1):14. PMID30616504 DOI
2018
Mogil LS, #*Andaleon A, #Badalamenti A, Dickinson SP, Guo X, Rotter JI, Johnson WC, Im HK, Liu Y, Wheeler HE. (2018) Genetic architecture of gene expression traits across diverse populations. PLOS Genetics 14(8):e1007586. PMID30096133 DOI
Wyss AB, Sofer T, Lee MK, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AV, Bartz TM, Feitosa MF, Gao W, Ahluwalia TS, Tang W, Oldmeadow C, Duan Q, de Jong K, Wojczynski MK, Wang XQ, Noordam R, Hartwig FP, Jackson VE, Wang T, Obeidat M, Hobbs BD, Huan T, Gui H, Parker MM, Hu D, Mogil LS, Kichaev G, Jin J, Graff M, Harris TB, Kalhan R, Heckbert SR, Paternoster L, Burkart KM, Liu Y, Holliday EG, Wilson JG, Vonk JM, Sanders JL, Barr RG, de Mutsert R, Menezes AMB, Adams HHH, van den Berge M, Joehanes R, Levin AM, Liberto J, Launer LJ, Morrison AC, Sitlani CM, Celedón JC, Kritchevsky SB, Scott RJ, Christensen K, Rotter JI, Bonten TN, Wehrmeister FC, Bossé Y, Xiao S, Oh S, Franceschini N, Brody JA, Kaplan RC, Lohman K, McEvoy M, Province MA, Rosendaal FR, Taylor KD, Nickle DC, Williams LK, Burchard EG, Wheeler HE, Sin DD, Gudnason V, North KE, Fornage M, Psaty BM, Myers RH, O’Connor G, Hansen T, Laurie CC, Cassano PA, Sung J, Kim WJ, Attia JR, Lange L, Boezen HM, Thyagarajan B, Rich SS, Mook-Kanamori DO, Horta BL, Uitterlinden AG, Im HK, Cho MH, Brusselle GG, Gharib SA, Dupuis J, Manichaikul A, London SJ. (2018) Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nature Communications 9(1):2976. PMID30061609 DOI
Li R, Kim D, Wheeler HE, Dudek SM, Dolan ME, Ritchie MD. (2018) Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity. The Pharmacogenomics Journal Epub 2018 May 25. PMID29795408 DOI
Barbeira AN, Dickinson SP, Bonazzola R, Zheng J, Wheeler HE, Torres JM, Torstenson ES, Shah KP, Garcia T, Edwards TL, Stahl EA, Huckins LM, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. (2018) Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nature Communications 9(1):1825. PMID29739930 DOI
#*Andaleon A, Mogil LS, Wheeler HE. (2018) Gene-based association study for lipid traits in diverse cohorts implicates BACE1 and SIDT2 regulation in triglyceride levels. PeerJ 6:e4314. PMID29404214 DOI
2017
Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton R, Vaughn DJ, Beard C, Fung C, Fossa SD, Hertz DL, Mushiroda T, Kubo M, Einhorn LH, Cox N, Travis L. (2017) Clinical and genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer. Clinical Cancer Research 23(19):5757-5768. PMID28611204
Wheeler HE, Gamazon ER, Frisina R, #Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman D, Hamilton R, Vaughn DJ, Beard C, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox N, Dolan ME, Travis L. (2017) Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Clinical Cancer Research 23(13):3325-33. PMID28039263 Highlights Feature
Wing C, Komatsu M, Delaney SM, Krause M, Wheeler HE, Dolan ME. (2017) Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy. Stem Cell Research 22:79-88. PMID28645005
Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME. (2017) Genetic variants contributing to colistin cytotoxicity: identification of TGIF1 and HOXD10 using a population genomics approach. International Journal Molecular Sciences 18(3). PMC5372673
2016
Wheeler HE, Shah KP, *Brenner J, Garcia T, Aquino-Michaels K, GTEx Consortium, Cox NJ, Nicolae DL, Im HK. (2016) Survey of the heritability and sparsity of gene expression traits across human tissues. PLOS Genetics 12(11):e1006423. PMC5106030
Frisina RD‡, Wheeler HE‡, Fossa SD, Kerns SL, Fung C, Sesso HD, Monahan PO, Feldman DR, Hamilton R, Vaughn DJ, Beard CJ, Budnick A, Johnson EM, Ardeshir-Rouhani-Fard S, Einhorn LH, Lipshultz SE, Dolan ME, Travis LB. (2016) Comprehensive audiometric analysis of hearing impairment and tinnitus after cisplatin-based chemotherapy in survivors of adult-onset cancer. Journal of Clinical Oncology 34(23):2712-20. PMC5019759 ‡Contributed equally.
Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel JN, Halabi S, Furukawa Y, Wheeler HE, Sibley A, Lassiter C, Weisman LS, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz D, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL. (2016) Pharmacogenetic discovery in CALGB (Alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy. Clinical Cancer Research 22(19):4890-4900. PMC5050068
2015
Gamazon ER‡, Wheeler HE‡, Shah KP‡, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. (2015) A gene-based association method for mapping traits using reference transcriptome data. Nature Genetics 47(9):1091-8. PMC4552594 ‡Contributed equally.
Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, Gorsic LK, Takahashi A, Kubo M, Kroetz D, Zhang W, Nakamura Y, Dolan ME. (2015) Pharmacoethnicity in paclitaxel-induced sensory peripheral neuropathy. Clinical Cancer Research 21(19):4337-46. PMC4592389
Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng JJ, Yang W, Fan Y, Wheeler HE, Wing C, Delaney SM, Komatsu M, Paugh SW, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui CH, Dolan ME, Relling MV, Evans WE. (2015) Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. JAMA 313(8):815-823. PMC4377066
Wheeler HE, Wing C, Delaney SM, Komatsu M, Dolan ME. (2015) Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells. PLOS One 10(2):e0118020. PMC4331516