Older publications

2013

Gorsic LK, Stark AL, Wheeler HE, Wong SS, Im HK, Dolan ME (2013) EPS8 inhibition increases cisplatin sensitivity in lung cancer cells. PLOS One 8(12):e82220. PMC3868552

Parsa A, Fuchsberger C…Wheeler HE…Böger CA (>100 authors) (2013) Common variants in Mendelian kidney disease genes and their association with renal function. Journal of the American Society of Nephrology 24(12):2105-17. PMC3839542

Eadon MT, Wheeler HE, Stark AL, Zhang X, Moen EL, Delaney SM, Im HK, Cunningham PN, Zhang W, Dolan ME (2013) Genetic and epigenetic variants contributing to clofarabine cytotoxicity. Human Molecular Genetics 22(19):4007-20. PMC3766179

Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME (2013) Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients. Blood 121(21):4366-76. PMC3663430

Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer E, Hudis C, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cox NJ, Dolan ME (2013) Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy. Clinical Cancer Research 19(2):491-9. PMC3549006

Wheeler HE, Maitland ML, Dolan ME, Cox NJ, Ratain MJ (2013) Cancer pharmacogenomics: strategies and challenges. Nature Reviews Genetics 14(1):23-34. PMC3668552

Wheeler HE, Gamazon ER, Stark AL, O’Donnell PH, Gorsic LK, Huang RS, Cox NJ, Dolan ME (2013) Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. The Pharmacogenomics Journal 13(1):35-43. PMC3370147

2012

Chasman DI, Fuchsberger C…Wheeler HE…Kao WH, Fox CS, Kottgen A (>100 authors) (2012) Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Human Molecular Genetics 21(24):5329-43. PMC3607468

Cox NJ, Gamazon ER, Wheeler HE, Dolan ME (2012) Clinical translation of cell-based pharmacogenomic discovery. Clinical Pharmacology & Therapeutics 92(4):425-7. PMC3664667

Madian AG, Wheeler HE, Jones RB, Dolan ME (2012) Relating human genetic variation to variation in drug responses. Trends in Genetics 28(10):487-95. PMC3448823

Stark AL, Delaney SM, Wheeler HE, Im HK, Dolan ME (2012) Functional consequences of PRPF39 on distant genes and cisplatin sensitivity. Human Molecular Genetics 21(19):4348-55. PMC3441128

Leandro-Garcia LJ, Lekela S, Jara Sanchez C, Green H, Avall Lundqvist E, Wheeler HE, Dolan ME, Inglada-Perez L, Maliszewska A, de Cubas AA, Comino-Mendez I, Mancikova V, Cascon A, Robledo M, Rodriguez-Antona C (2012) Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy. Clinical Cancer Research 18(16):4441-8. PMC3664665

O’Donnell PH, Stark AL, Gamazon ER, Wheeler HE, McIlwee BE, Gorsic LK, Im HK, Huang RS, Cox NJ, Dolan ME (2012) Identification of novel germline polymorphisms governing capecitabine sensitivity. Cancer 118(16):4063-73. PMC3413892

Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA…Wheeler HE…Kao WH, Fox CS (>100 authors) (2012) Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584. PMC3315455

Njiaju UO, Gamazon ER, Gorsic LK, Delaney SM, Wheeler HE, Im HK, Dolan ME (2012) Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel. Pharmacogenetics and Genomics 22(7): 498-507. PMC3376193

Wheeler HE and Dolan ME. (2012) Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. Pharmacogenomics 13(1):55-70. PMC3292907

2011

Wheeler HE, Gorsic LK, Welsh M, Stark AL, Gamazon ER, Cox NJ, Dolan ME. (2011) Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One 6(7): e21920. PMC3130766

Wen Y, Gorsic LK, Wheeler HE, Ziliak DM, Huang RS, Dolan ME. (2011) Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies. Pharmacogenetics and Genomics 21(8): 476-88. PMC3134538

Wheeler HE and Kim SK (2011) Genetics and genomics of human ageing. Philosophical Transactions of the Royal Society B 366(1561): 43-50. PMC3001305

2009

Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. (2009) Sequential use of transcriptional profiling, expression quantitative trait mapping and gene association implicates MMP20 in human kidney aging. PLoS Genetics 5(10): e1000685. PMC2752811