Wheeler Lab Member     *Masters Student     #Undergraduate

2024

American Society of Human Genetics Annual Meeting, Denver, CO, November 5-9, 2024. #*I. Gregga, C. Choo-Kang, A. Luke, P. Bovet, E. V. Lambert, D. E. Rae, K. Bedu-Addo, J. Plange Rhule, T. Forrester, L. R. Dugas, H. E. Wheeler. Transcriptome prediction and BMI polygenic risk score performance varies across African genetic ancestries populations from four diverse environments. Poster Presentation.

American Society of Human Genetics Annual Meeting, Denver, CO, November 5-9, 2024. #*Patel M, #Chilton G, Wheeler HE. Refining cross-population polygenic risk scores to optimize trait prediction in diverse populations. Poster Presentation.

American Society of Human Genetics Annual Meeting, Denver, CO, November 5-9, 2024. #Sharma MZ, Wheeler HE. Multi-ancestry GWAS and TWAS implicate cell adhesion in anxiety related phenotypes. Poster Presentation.

American Society of Human Genetics Annual Meeting, Denver, CO, November 5-9, 2024. #Kolbunova E, Wheeler HE. Genomic indicators of female infertility using transcriptome-wide association studies in a European Population. Poster Presentation.

American Society of Human Genetics Annual Meeting, Denver, CO, November 5-9, 2024. #Trivedi V, Wheeler HE. Comparison of gestational and type 2 diabetes mellitus transcriptome-wide association studies in South Asian and multi-ancestries populations. Poster Presentation.

2023

American Society of Human Genetics Annual Meeting, Washington, DC, November 1-5, 2023. #*Wittich H, Rich SS, Rotter JI, Im HK, Manichaikul AW, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. The genetically regulated transcriptome better predicts plasma protein levels than the observed transcriptome and reveals mechanisms underlying autoimmune diseases. Poster Presentation.

American Society of Human Genetics Annual Meeting, Washington, DC, November 1-5, 2023. #Chilton G, #Bozeman K, #*Patel M, Wheeler HE. Genetically regulated gene expression influences chronotype and sleep duration in diverse populations. Poster Presentation.

2022

American Society of Human Genetics 72nd Annual Meeting, Los Angeles, CA, October 25-29, 2022. *Araújo DS, #Nguyen C, Rich SS, Rotter JI, Im HK, Manichaikul AW, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Multiadaptive shrinkage improves cross-population transcriptome prediction models for transcriptome-wide association studies in underrepresented populations. Platform Presentation.

American Society of Human Genetics 72nd Annual Meeting, Los Angeles, CA, October 25-29, 2022. #*Wittich H, Rich SS, Rotter JI, Im HK, Manichaikul AW, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Performing TWAS on proteomic data to understand cis and trans gene regulatory mechanisms underlying complex traits. Platform Presentation.

American Society of Human Genetics 72nd Annual Meeting, Los Angeles, CA, October 25-29, 2022. #Gregga I, Rosenow W, Prins B, Butterworth A, Pharoah P, Gayther S, Manichaikul A, Im HK, Kar S, Schildkraut J, Wheeler HE. Proteome association studies of breast, prostate, ovarian, and endometrial cancers implicate plasma protein regulation in cancer susceptibility. Reviewers’ Choice (top 10%) Poster.

CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Conference, Seattle, WA, October 12-14, 2022. #*Wittich H, Rich SS, Rotter JI, Im HK, Manichaikul AW, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Performing TWAS on proteomic data to understand cis and trans gene regulatory mechanisms underlying complex traits. Proteomics Working Group Presentation.

Intelligent Systems for Molecular Biology Conference, Madison, WI, July 10-14, 2022. #*Wittich H, Wheeler HE. Incorporating the Genetically Regulated Transcriptome into the Analysis of Protein Expression. Poster.

CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Conference, Philadelphia, PA, April 27-29, 2022. *Araújo DS, Rich SS, Rotter JI, Im HK, Manichaikul A, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Improving cross-population transcriptome prediction models for transcriptome-wide association studies in underrepresented populations. Poster and Travel Award.

2021

American Society of Human Genetics 71st Annual Meeting, Virtual, October 18 - 22, 2021. *Schubert R, #Gregga I, #*Geoffroy E, #*Mulford A, Manichaikul AW, Im HK, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Protein prediction for trait mapping in diverse populations. Platform Presentation.

American Society of Human Genetics 71st Annual Meeting, Virtual, October 18 - 22, 2021. *Araújo D, Rich SS, Rotter JI, Im HK, Manichaikul AW, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Mitochondrial and sex chromosome genetically regulated gene expression implicates new genes in complex traits across multiple human populations. Reviewers’ Choice (top 10%) Poster.

Intelligent Systems for Molecular Biology Conference and European Conference of Computational Biology, Virtual, July 25 - 30, 2021. *Okoro PC, *Schubert R, Guo X, Johnson WC, Rotter JI, Hoeschele I, Liu Y, Im HK, Luke A, Dugas LR, Wheeler HE. Elastic net outperforms other machine learning models in gene expression prediction across global ancestries. Poster.

Great Lakes Bioinformatics Conference, Virtual, May 10 - 13, 2021. #*Mulford AJ, Wing C, *Schubert R, Manichaikul A, Im HK, Dolan ME, Wheeler HE. Multi-omic association studies identify novel genes and proteins regulating cellular sensitivity to chemotherapy in diverse populations. Oral Presentation.

2020

American Society of Human Genetics 70th Annual Meeting, Virtual, October 27 - 30, 2020. *Schubert R, #*Mulford A, Thornton TA, Gignoux CR, Lange LA, Lange E, Lappalainen T, Gerszten R, Rich SS, Rotter JI, Cho M, Manichaikul AW, Im, HK, Wheeler HE, on behalf of the NHLBI TOPMed Consortium. Multi-ethnic fine mapping optimizes proteome association studies. Platform Presentation.

American Society of Human Genetics 70th Annual Meeting, Virtual, October 27 - 30, 2020. #*Mulford A, Wing C, Dolan ME, Wheeler HE. STARD5 Expression is associated with etoposide cytotoxicity in diverse populations. Poster.

American Society of Human Genetics 70th Annual Meeting, Virtual, October 27 - 30, 2020. #*Geoffroy E, #Gregga I, Wheeler HE. Population matched transcriptome prediction increases discovery and replication rate in TWAS. Reviewers’ Choice (top 10%) Poster.

Intelligent Systems for Molecular Biology, Virtual, July 13 - 16, 2020. #*Mulford A, Wing C, Dolan ME, Wheeler HE. Transcriptome-wide association studies identify novel genes associated with chemotherapy toxicity in human lymphoblastoid cell lines from diverse populations. Poster.

Intelligent Systems for Molecular Biology, Virtual, July 13 - 16, 2020. #*Geoffroy E, #Gregga I, #Takamura J, Wheeler HE. Inferring gene-trait associations with diverse population gene expression prediction models. Poster.

2019

ISCB-Africa ASBCB Conference on Bioinformatics, International Society for Computational Biology and the African Society for Bioinformatics and Computational Biology, Kumasi, Ghana, November 11 - 15, 2019. *Okoro P, *Schubert R, Luke A, Dugas LR, Wheeler HE. Machine learning performance for gene expression prediction across global populations. Oral Presentation.

World Congress of Psychiatric Genetics, Los Angeles, CA, October 26 - 31, 2019. #Fiorica PN, Wheeler HE. Gene-based association study of schizophrenia and bipolar disorder in African Americans. Poster.

American Society of Human Genetics 69th Annual Meeting, Houston, TX, October 15 - 19, 2019. *Okoro P, *Schubert R, Luke A, Dugas LR, Wheeler HE. Optimizing gene expression predictive performance across global populations. Platform Presentation.

American Society of Human Genetics 69th Annual Meeting, Houston, TX, October 15 - 19, 2019. #Fiorica PN, #Abdul Sami M, #Morris JD, Wheeler HE. Transcriptome-wide association study in African Americans identifies associations with prostate cancer. Platform Presentation.

American Society of Human Genetics 69th Annual Meeting, Houston, TX, October 15 - 19, 2019. *Schubert R, *Okoro P, Luke A, Dugas LR, Wheeler HE. Linkage disequilibrium pruning improves gene expression prediction across diverse populations. Poster.

Midwest Population Genetics 6th Annual Meeting, Chicago, IL, August 16 - 17, 2019. *Schubert R, *Andaleon A, Wheeler HE. Benchmarking local ancestry inference in populations of two- and three-way admixture. Oral Presentation.

Great Lakes Bioinformatics Conference, Madison, WI, May 19-22, “The genetic architecture of expression and splicing in African ancestry populations” Schubert R, *Okoro P, Luke A, Dugas L, Wheeler HE. Poster.

Great Lakes Bioinformatics Conference, Madison, WI, May 19-22, “Gene Expression Prediction: A Machine Learning Approach” *Okoro P, Schubert R, Luke A, Dugas L, Wheeler HE. Oral Presentation.

Great Lakes Bioinformatics Conference, Madison, WI, May 19-22, “Optimizing Gene Predictors in Diverse Populations” #Takamura J, #Geoffroy E, Wheeler HE. Poster.

Great Lakes Bioinformatics Conference, Madison, WI, May 19-22, “Genetically regulated gene expression underlies lipid traits in Hispanic cohorts” *Andaleon A, Mogil LS, Wheeler HE. Oral Presentation.

Great Lakes Bioinformatics Conference, Madison, WI, May 19-22, “Imputed gene associations identify replicable trans-acting genes enriched in immune traits” Wheeler, HE. Oral Presentation.

2018

American Society of Human Genetics 68th Annual Meeting, San Diego, CA, October 16 - 20, 2018. *Andaleon A, Mogil LS, Wheeler HE. Transcriptome-based association study in Hispanic cohorts implicates novel genes in lipid traits. Platform Presentation.

American Society of Human Genetics 68th Annual Meeting, San Diego, CA, October 16 - 20, 2018. #Fiorica PN, Wheeler HE. Predicting the genetic regulation of schizophrenia in African American populations. Poster.

American Society of Human Genetics 68th Annual Meeting, San Diego, CA, October 16 - 20, 2018. Wheeler HE, #Ploch S, Barberia AN, Im HK. Imputed gene associations identify replicable trans-acting/target gene pairs and suggest a larger trans than cis contribution to complex trait architecture. Poster.

International Genetic Epidemiology Society 27th Annual Meeting, San Diego, CA, October 13 - 16, 2018. Wheeler HE, #Ploch S, Barberia AN, Im HK. Imputed gene associations identify replicable trans-acting and target gene pairs enriched in transcription factor pathways. Platform Presentation.

International Genetic Epidemiology Society 27th Annual Meeting, San Diego, CA, October 13 - 16, 2018. *Andaleon A, Mogil LS, #Badalamenti A, Dickinson SP, Guo X, Rotter JI, Johnson WC, Im HK, Liu Y, Wheeler HE. Genetic architecture of gene expression traits across diverse populations. Poster Highlight Talk.

Intelligent Systems for Molecular Biology Conference, Chicago, IL, July 6-10, Poster: “Gene-based association study for lipid traits in diverse cohorts” #Angela Andaleon, Lauren S. Mogil, Heather E. Wheeler

Intelligent Systems for Molecular Biology Conference, Chicago, IL, July 6-10, Lightning Talk and Poster: “Imputed gene associations identify replicable trans-acting genes enriched in transcription pathways” Heather E. Wheeler, #Sally Ploch, Alvaro Barbeira, Hae Kyung Im

Closing the Genomics Research Gap: An International Symposium on Genomics and Health, Montreal, QC, June 15-17, Poster: “Genetic architecture of gene expression traits across diverse populations” Lauren S. Mogil, #Angela Andaleon, #Alexa Badalamenti, Scott P. Dickinson, Xiuqing Guo, Jerome I. Rotter, W. Craig Johnson, Hae Kyung Im, Yongmei Liu, Heather E. Wheeler

Chicago Area Undergraduate Research Symposium, DePaul University, Chicago, IL, April 15, Poster: “Contrasting and Correlating Prostate Cancer Genetic Susceptibility Loci in Multiple Populations “ #Mohammed Abdul Sami, #Jack Morris, Heather E. Wheeler

Chicago Area Undergraduate Research Symposium, DePaul University, Chicago, IL, April 15, Poster: “Predicting the Genetic Regulation of Schizophrenia in African American Populations” #Peter Fiorica, Heather E. Wheeler

Chicago Area Undergraduate Research Symposium, DePaul University, Chicago, IL, April 15, Poster: “Optimizing Gene Predictors in Diverse Populations” #Jennifer Takamura, Heather E. Wheeler

Chicago Area Undergraduate Research Symposium, DePaul University, Chicago, IL, April 15, Poster: “Gene-based association study for lipid traits in diverse cohorts implicates BACE1 and SIDT2 regulation in triglyceride levels” #Angela Andaleon, Heather E. Wheeler

2017

American Society of Human Genetics Annual Meeting, Orlando, FL, October 17-21, Poster: “Gene expression predictive performance varies across diverse populations” Lauren Mogil, #Alexa Badalamenti, Heather E. Wheeler

Great Lakes Bioinformatics Conference, Chicago, IL, May 15-17, Presentation: “Optimizing predictors of gene expression within and across diverse populations” Lauren Mogil, Heather E. Wheeler

Great Lakes Bioinformatics Conference, Chicago, IL, May 15-17, Poster: “Gene expression predictive performance varies across populations” #Alexa Badalamenti, #Virginia Saulnier, #Natalie Jachym, *Amani Almatrafi, #Jeffrey Ng, #Shyam Shah, Heather E. Wheeler

Great Lakes Bioinformatics Conference, Chicago, IL, May 15-17, Poster: “Transcriptome-based Association Study Comparing Susceptibility to Multiple Cancer Types” #Danny Baghdan, Lauren Mogil, #Carlos Perez-Cervantes, Heather E. Wheeler

Chicago Area Undergraduate Research Symposium, Roosevelt University, Chicago, IL, April 29, Poster: “Genetic Mechanisms Underlying Cholesterol Traits in Diverse Populations” #Angela Andaleon, Heather E. Wheeler

2016

American Society of Human Genetics Annual Meeting, Vancouver, BC, October 18 - 22, Poster: “Predicting gene regulation in diverse global populations” #Alexa Badalamenti, #Natalie Jachym, *Amani Almatrafi, #Virginia Saulnier, #Jeffrey Ng, #Shyam Shah, Heather E. Wheeler

American Society of Human Genetics Annual Meeting, Vancouver, BC, October 18 - 22, Platform Presentation: “Genome-wide association study with replication implicates WFS1 in cisplatin-associated hearing loss and reveals an enrichment of SNPs in Mendelian genes for deafness” Heather E. Wheeler, Eric R. Gamazon, Robert D. Frisina, #Carlos Perez-Cervantes, Omar El Charif, Sophie D. Fossa, Darren R. Feldman, Robert Hamilton, David J. Vaughn, Clair J. Beard, Chunkit Fung, Lawrence H. Einhorn, Christian Kollmannsberger, Jeri Kim, Taisei Mushiroda, Michiaki Kubo, Shirin Ardeshir-Rouhani-Fard, Nancy J. Cox, M. Eileen Dolan, Lois B. Travis, The Platinum Study Group

American Society of Clinical Oncology Annual Meeting, Chicago, IL, June 3 - 7, Poster with Discussion Session: “Genome-wide association study of cisplatin-related hearing loss in testicular cancer survivors to reveal associated variant in Wolfram syndrome 1 (WFS1) gene” Heather E. Wheeler, Robert D. Frisina, Eric R. Gamazon, Omar El Charif, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Clair J. Beard, Chunkit Fung, Lawrence H. Einhorn, Sophie D. Fossa, Taisei Mushiroda, Michiaki Kubo, Nancy J. Cox, M. Eileen Dolan, Lois B. Travis for The Platinum Study Group

Great Lakes Bioinformatics and the Canadian Computational Biology Conference, Toronto, ON, May 16 - 19, Poster: “Predicting Gene Regulation in Diverse Global Populations” #Virginia Saulnier, #Alexa Badalamenti, #Jeffrey Ng, #Shyam Shah, Heather E. Wheeler

Great Lakes Bioinformatics and the Canadian Computational Biology Conference, Toronto, ON, May 16 - 19, Presentation: “Survey of the Heritability and Sparsity of Gene Expression Traits Across Human Tissues” Heather E. Wheeler, Kaanan P. Shah, *Jonathon Brenner, GTEx Consortium, Hae Kyung Im

Chicago Area Undergraduate Research Symposium, The Museum of Science and Industry, Chicago, IL, April 9, Poster: “Gene-Based Association Study of Sporadic Postmenopausal Breast Cancer” #Carlos Perez-Cervantes, Heather E. Wheeler

Chicago Area Undergraduate Research Symposium, The Museum of Science and Industry, Chicago, IL, April 9, Poster: “Predicting Gene Regulation in Diverse Global Populations” #Alexa Badalamenti, #Jeffrey Ng, #Virginia Saulnier, #Shyam Shah, Heather E. Wheeler

2015

American Society of Human Genetics Annual Meeting, Baltimore, MD, October 6-10, Reviewers’ Choice (top 10%) Poster: “Genetic architecture of gene expression regulation via orthogonal tissue decomposition” Heather E. Wheeler, Nicholas Knoblauch, GTEx Consortium, Nancy J. Cox, Dan L. Nicolae, Hae Kyung Im